Class: AMRDeterminant

A gene or mutation that confers antimicrobial resistance, classified with the Antibiotic Resistance Ontology (ARO).

URI: [micokg:AMRDeterminant](https://w3id.org/micokg/AMRDeterminant)

 classDiagram
    class AMRDeterminant
    click AMRDeterminant href "../AMRDeterminant/"
      FunctionalGene <|-- AMRDeterminant
        click FunctionalGene href "../FunctionalGene/"

      AMRDeterminant : aro_class

      AMRDeterminant : confers_resistance_to

      AMRDeterminant : description

      AMRDeterminant : gene_family

      AMRDeterminant : gene_symbol

      AMRDeterminant : genomic_context

      AMRDeterminant : has_function

      AMRDeterminant : id

      AMRDeterminant : in_taxon

      AMRDeterminant : name

      AMRDeterminant : resistance_mechanism

## Inheritance * [NamedThing](NamedThing.md) * [FunctionalGene](FunctionalGene.md) * **AMRDeterminant** ## Class Properties | Property | Value | | --- | --- | | Class URI | [micokg:AMRDeterminant](https://w3id.org/micokg/AMRDeterminant) | ## Slots | Name | Cardinality and Range | Description | Inheritance | | --- | --- | --- | --- | | [aro_class](aro_class.md) | 1
[Uriorcurie](Uriorcurie.md) | The ARO gene family or determinant class | direct | | [confers_resistance_to](confers_resistance_to.md) | *
[Uriorcurie](Uriorcurie.md) | Drug or drug class (ARO drug class or CHEBI antimicrobial agent) | direct | | [resistance_mechanism](resistance_mechanism.md) | 0..1
[Uriorcurie](Uriorcurie.md) | ARO resistance mechanism, e | direct | | [gene_symbol](gene_symbol.md) | 0..1
[String](String.md) | Gene symbol or name as given by the source, e | [FunctionalGene](FunctionalGene.md) | | [gene_family](gene_family.md) | *
[Uriorcurie](Uriorcurie.md) | KEGG orthology, EC number or Pfam family | [FunctionalGene](FunctionalGene.md) | | [has_function](has_function.md) | *
[Uriorcurie](Uriorcurie.md) | Gene Ontology terms for the gene's molecular function or biological process | [FunctionalGene](FunctionalGene.md) | | [in_taxon](in_taxon.md) | 0..1
[Uriorcurie](Uriorcurie.md) | The taxon this host or gene belongs to | [FunctionalGene](FunctionalGene.md) | | [genomic_context](genomic_context.md) | 0..1
[Uriorcurie](Uriorcurie.md) | e | [FunctionalGene](FunctionalGene.md) | | [id](id.md) | 1
[Uriorcurie](Uriorcurie.md) | CURIE or IRI | [NamedThing](NamedThing.md) | | [name](name.md) | 0..1
[String](String.md) | Human-readable label | [NamedThing](NamedThing.md) | | [description](description.md) | 0..1
[String](String.md) | Free-text description | [NamedThing](NamedThing.md) | ## Usages | used by | used in | type | used | | --- | --- | --- | --- | | [Container](Container.md) | [amr_determinants](amr_determinants.md) | range | [AMRDeterminant](AMRDeterminant.md) | ## Identifier and Mapping Information ### Schema Source * from schema: https://w3id.org/micokg ## Mappings | Mapping Type | Mapped Value | | --- | --- | | self | micokg:AMRDeterminant | | native | micokg:AMRDeterminant | | close | ARO:3000000 | ## LinkML Source ### Direct

name: AMRDeterminant
description: A gene or mutation that confers antimicrobial resistance, classified
  with the Antibiotic Resistance Ontology (ARO).
from_schema: https://w3id.org/micokg
close_mappings:
- ARO:3000000
is_a: FunctionalGene
slots:
- aro_class
- confers_resistance_to
- resistance_mechanism
slot_usage:
  aro_class:
    name: aro_class
    required: true
class_uri: micokg:AMRDeterminant

### Induced

name: AMRDeterminant
description: A gene or mutation that confers antimicrobial resistance, classified
  with the Antibiotic Resistance Ontology (ARO).
from_schema: https://w3id.org/micokg
close_mappings:
- ARO:3000000
is_a: FunctionalGene
slot_usage:
  aro_class:
    name: aro_class
    required: true
attributes:
  aro_class:
    name: aro_class
    description: The ARO gene family or determinant class.
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: micokg:aro_class
    owner: AMRDeterminant
    domain_of:
    - AMRDeterminant
    range: uriorcurie
    bindings:
    - range: AMRDeterminantEnum
      obligation_level: RECOMMENDED
    required: true
    pattern: ^ARO:\d{7}$
  confers_resistance_to:
    name: confers_resistance_to
    description: Drug or drug class (ARO drug class or CHEBI antimicrobial agent).
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: micokg:confers_resistance_to
    owner: AMRDeterminant
    domain_of:
    - AMRDeterminant
    range: uriorcurie
    multivalued: true
    pattern: ^(ARO|CHEBI):\d+$
  resistance_mechanism:
    name: resistance_mechanism
    description: ARO resistance mechanism, e.g. antibiotic inactivation.
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: micokg:resistance_mechanism
    owner: AMRDeterminant
    domain_of:
    - AMRDeterminant
    range: uriorcurie
    pattern: ^ARO:\d{7}$
  gene_symbol:
    name: gene_symbol
    description: Gene symbol or name as given by the source, e.g. blaCTX-M-15.
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: micokg:gene_symbol
    owner: AMRDeterminant
    domain_of:
    - FunctionalGene
    range: string
  gene_family:
    name: gene_family
    description: KEGG orthology, EC number or Pfam family.
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: micokg:gene_family
    owner: AMRDeterminant
    domain_of:
    - FunctionalGene
    range: uriorcurie
    multivalued: true
  has_function:
    name: has_function
    description: Gene Ontology terms for the gene's molecular function or biological
      process.
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: RO:0000085
    owner: AMRDeterminant
    domain_of:
    - FunctionalGene
    range: uriorcurie
    multivalued: true
    pattern: ^GO:\d{7}$
  in_taxon:
    name: in_taxon
    description: The taxon this host or gene belongs to.
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: RO:0002162
    owner: AMRDeterminant
    domain_of:
    - Host
    - FunctionalGene
    range: uriorcurie
    bindings:
    - range: TaxonEnum
      obligation_level: RECOMMENDED
    pattern: ^(NCBITaxon:\d+|GTDB:.+)$
  genomic_context:
    name: genomic_context
    description: e.g. SO:0000155 plasmid, SO:0000340 chromosome.
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: micokg:genomic_context
    owner: AMRDeterminant
    domain_of:
    - FunctionalGene
    range: uriorcurie
    pattern: ^SO:\d{7}$
  id:
    name: id
    description: CURIE or IRI. Reuse ontology IDs; mint micokg:<type>/<local-id> for
      instances.
    from_schema: https://w3id.org/micokg
    rank: 1000
    identifier: true
    owner: AMRDeterminant
    domain_of:
    - NamedThing
    range: uriorcurie
    required: true
  name:
    name: name
    description: Human-readable label.
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: rdfs:label
    owner: AMRDeterminant
    domain_of:
    - NamedThing
    range: string
  description:
    name: description
    description: Free-text description.
    from_schema: https://w3id.org/micokg
    rank: 1000
    slot_uri: dct:description
    owner: AMRDeterminant
    domain_of:
    - NamedThing
    range: string
class_uri: micokg:AMRDeterminant